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The Novo Nordisk Foundation and Broad Institute of MIT and Harvard launch a new research center for genomic mechanisms of disease

The Novo Nordisk Foundation and Broad Institute of MIT and Harvard launch a new research center for genomic mechanisms of disease

The Novo Nordisk Foundation announced today the launch of the Center for Genomic Mechanisms of Disease, an initiative that will accelerate efforts to mine genetic data for insights into disease mechanisms, and eventually rationally designed treatments.

The Center will generate systematic data to help researchers understand the impact of human genetic variants on the complex diseases. Based on an initiative in Cambridge, MA, funded by the Foundation, the Center supports a grant of up to $47.5 million, All the datasets will be shared freely with the research community. The Center's principal activity is to promote and facilitate close collaborations between the Broad Institute and Danish universities, with the focus first being on understanding type 2 diabetes and obesity and mapping human gene regulation. The Center will join the international common disease alliance, sharing data, methodology and tools, and work in common cause with investigators from other large-scale efforts such as the Accelerating Medicines Partnership in Common Metabolic Diseases and the

The Center's research collaboration aims to advance patient-centered research and precision medicine. The Center will establish a exchange program to provide Danish scientists with opportunities to study genomic technologies at the Broad Institute. These collaborations will catalyze and contribute to the development of biomedical research in Denmark.

The Broad Institute has established a reputation as renowned international epicenter for biomedical research and innovation and it is recognized as the key nexus of this rich ecosystem, says Niels-Henrik von Hol We seek to help drive global research in health for many.

The Broad community has long believed that international collaboration is crucial to advancing our knowledge of human disease and to getting more quickly benefits to patients, said Todd Golub, director of the Broad Institute. The Center for Genomic Mechanisms of Disease is a natural extension of our deep commitment to global collaborations, but also our pursuit of foundational research."

The new center will be directed by Broad Institute associate member Kasper Lage, who has also played an important role in the planning and development of the initiative since it was conceived in 2019.

"As a Dane and sa long-time member of the Broad Institute community, I'm thrilled with the launch of this exciting new center," said Lage. "He is renowned for his opportun This collaboration initiative will give the next generation of Danish scientists the opportunity to benefit from Broad's unique technology platforms and our expertise in genomics, gene regulation, and data science. I appreciate the enormous vision of the Novo Nordisk Foundation for this new collaborative initiative and the immense vision that made this exciting partnership possible. I thank everyone there who helped make this wonderful partnership happen.

Research will be carried out at the Broad Institute and Danish institutions, with exchange of scientists and dedicated training for Danish researchers.

The Center will help the next generation of talented researchers, and also support them. According to Juleen R. Zierath, executive director of the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen, who will join the Steering Committee of center at Broad Institute, the center " We are delighted to see the possibility that Danish scientists train at this center, where they can access Broad's leading scientific capabilities and learn from them, and to bring new technologies and skills that will lead to new advances in precision medicine."

Initially, the Novo Nordisk Foundation has committed its commitment for a five-year period (2021-2026) with the possibility of extending its support of the centre.

About the Novo Nordisk Foundation. The Novo Nordisk Foundation is a Danish independent foundation with corporate interests. It has two objectives: 1) to establish a stable base for the commercial and research activities of the Novo Group companies; and 2) to support scientific, human, and social causes.

The Foundation's vision is to contribute significantly to the research and development that improves the lives of people and the sustainability of society. Since 2010, the Foundation has donated more than 30 billion dKK (4 billion) in the u.s., mainly for research in public institutions and hospitals in Denmark and other Nordic countries. Read more at www.novonordiskfonden.dk/en/.

About the Broad Institute of MIT and Harvard, about the UMBC Broad and MU. About The Broad Observatory and the Harvard University. The Broad Institute of MIT and Harvard was founded in 2003 to enable this generation of creative scientists to transform medicine with new genome-based knowledge. The Broad Institute seeks to explain the molecular components of life and their connections, to discover the fundamentals of human diseases, develop effective new approaches to diagnostic and therapeutics and distribute discoveries, tools, methods and data to the entire scientific

With collaborations spanning over 40 countries worldwide, the Broad Institute is founded by the MIT and Harvard hospital and the visionary Los Angeles philanthropists Eli and Edythe Broad. The Broad Research Institute includes faculty, For more information about the Broad Institute, visit www.broadinstitute.org.

SOURCE Broad Institute of MIT and Harvard, a SUMBE Broadcast Institute, and the SESSCE Boston Institute.

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