Co-cultures in Bioprocessing Control

Co-cultures in Bioprocessing Control ...

Bioprocessors may be able to produce biopharmaceuticals more efficiently by adding another cell line to the process, according to Seetharaman Vaidyanathan, a senior lecturer in chemical engineering at the University of Sheffield in the United Kingdom, and his colleagues.

Vaidyanathan discusses the benefits of co-culturing in bioprocessing a biopharmaceutical as it adds an additional layer of control to productivities in an interview with GEN.

Co-culturing is a way to create multiple products or components that can be reassembled or modified ex vivo, as well as using process analytical technology (PAT), according to Vaidyanathan.

The need to overcome significant hurdles

However, to achieve these goals, it requires overcoming certain tough challenges. The first that Vaidyanathan mentions is establishing stable co-cultures that have sustainably desired characteristics. A bioprocessor must also be careful about side effects, which might produce a less stable product. Even the overall management of bioprocessing must be adjusted, which Vaidyanathan describes as implementing a protocol that requires transcending conventional industrial practices of monocultures.

Vaidyanathan explains that many of the new developments are occurring in microbial co-cultures, but there isn't much reason to imagine why they might not be implemented in other hosts where relevant. Overall, incorporating co-cultures in commercial bioprocessing is a significant step. As Vaidyanathan says, it requires a paradigm shift in mindset.

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