What Does the Cerebellum Affect Absence Seizures?

What Does the Cerebellum Affect Absence Seizures? ...

The results from the Ruhr-Universitat Bochum Behavioral Neuroscience group were revealed in the journal Cellular and Molecular Life Sciences from 19 March 2022. They worked with Bonn, Munster, and Munchen, and each of the participants.

Abrupt loss of consciousness

Necessary mal seizures are often observed in children between the ages of four to twelve, often due to a long term deficit in cognition. These include abnormal neural activity, which is often detected in brain activity recordings as so-called spike-and-wave discharges. The characteristic activity pattern is based on the rhythmic and synchronized activity of nerve cells in the cerebral cortex and thalamus.

Since the nuclei embedded in the cerebellum have a large connectivity to various areas of the brain, researchers suggested that stimulation of the cerebellar nuclei might help stop absence seizures. However, it is unclear what is underlying this hypothesis at the cellular and molecular level.

Cerebellar stimulation is appropriate to treat abnormal brain activity.

Researchers from Bochum worked with mice that developed absence seizures due to a lack of the P/Q-type calcium channel in the cerebellum cells. They found that cells of the cerebellar nuclei were firing abnormally, and that stimulation of these cells could prevent further SWDs. Therefore, they developed a genetically modified receptor into the cells, which was then stimulated by a specific specific molecule normally not present in the brain. This allowed the researchers to slowly increase the activity of the cerebellar nuclei cells

Moreover, the team used optogenetic stimulation to bolster cell activity in the cerebellar nuclei and to stop on-going SWDs after they have begun. This technique, used by algae, can be placed on by light to increase the activity of nerve cells. Overall, the study indicated that targeted stimulation of the cerebellar nuclei might become a therapeutic therapy for patients with absence seizures.

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