Responses to a Low-Protein Diet, directed by a Single Hormone, are made by Bodys

Responses to a Low-Protein Diet, directed by a Single Hormone, are made by Bodys ...

A single hormone appears to improve the lifespan of a low-protein diet.

A recent study from the Pennington Biomedical Research Center uncovered that reducing the amount of protein in the diet provided a range of beneficial health benefits, including an extended lifespan, and that these effects depend on a liver-derived metabolic hormone called Fibroblast Growth Factor 21 (FGF21).

Several studies suggest that eating low in protein and amino acid levels may benefit health. Several studies suggest that eating low in protein or amino acid levels can improve health. Conversely, overconsumption of high-protein foods has been linked to increased mortality in certain age groups.

During protein restriction, Pennington Biomedicals Neurosignaling Laboratory discovered that the metabolic hormone FGF21 was a key signal linking the body to the brain. Eventually, young mice failed to modify their feeding behavior or metabolism when placed on a low-protein diet.

Our findings suggest that FGF21 talks to the brain, and that without this sign the mouse does not know that it is eating a low-protein diet. According to Christopher Morrison, the mouse fails to adapt its metabolism or feeding behavior.

Low-protein foods, led by Cristal M. Hill, a postdoctoral researcher, demonstrate that low-protein diets may benefit from beneficial metabolic effects in aged mice, while also improving metabolic health, frailty, and prolonging lifespan. These beneficial effects were also apparent when protein intake was reduced in middle-aged mice, thus reducing frailty, and prolonging lifespan. This important element is that protein intake in the brain is critical for improving health and longevity.

We previously demonstrated that FGF21 acts in the brain in order to improve metabolic health in young mice fed a low-protein diet. Together, these findings highlight that FGF21 is also beneficial to metabolic health and improves longevity. Together, these findings further demonstrate that FGF21 is the first known hormone that enhances feeding behavior and metabolic health to prolong lifespan during protein restriction.

Despite the fact that several questions remain remain. It''s unclear how these observations will impact aging humans, but the hope is that this study will uncover novel molecular and neural pathways that can be used to improve health in individuals.

This innovative research has significant implications for extending people''s health and lifespan. According to Pennington Biomedical Executive Director John Kirwan, a PhD, believes that diets and nutritional hormones like FGF21 may be beneficial to prolong life.

You may also like: