Preclinical models using the timsTOF and MALDI-2 platforms to assess Pharmacodynamics and Pharmacokinetics

Preclinical models using the timsTOF and MALDI-2 platforms to assess Pharmacodynamics and Pharmacoki ...

For successful therapeutic transmission to the clinic, a comprehensive evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential. However, cost-effective methods to measure these parameters at the systems level in pre-clinical studies are lacking. We introduce a timsTOF and MALDI-2 workflow to assess therapeutic activity. We have developed a therapeutic activity evaluation methodology using vivo isotope tracing and the global metabolome analysis in the adult zebrafish.

  • Learn about innovative metabolomics workflows
  • Discover how the Bruker timsTOF Pro and fleX systems can be used in metabolomics workflows
  • Learn how the MALDI-2 post-ionization laser can see never before observed compounds

*Not for diagnostic purposes; *For Research Use Only.

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