Schizophrenia is a serious psychiatric disorder that begins in early adolescence or early adulthood and affects around one in 300 people across the world, according to the World Health Organization.
Specific genes were identified in an a paper published April 8 inNature, which said it might play important roles in the psychiatric disorder. In the largest genetic study of schizophrenia, researchers including Ayman Fanous, MD, analysed DNA from 76,755 people with schizophrenia and 243,649 without it to better understand the genes and biological processes beneath the condition.
According to Fanous, the chair of the Department of Psychiatry at the University of Arizona Medical Center Phoenix, previous research has shown ties between schizophrenia and many DNA sequence changes, but it was rare that the findings be linked to specific genes.
Many of these genes have been linked to specific genes, which is a necessary step in a largely difficult journey towards understanding the causes of this condition and recommending new therapies.
Dr. Fanous was a member of the Psychiatric Genomics Consortium, which includes hundreds of researchers in 45 countries.
In 287 different parts of the genome, the human body''s DNA blueprint, a lot of genetic links to schizophrenia were discovered.
The project is the largest ever to date on the genome; the research team has identified a significant increase in the number of schizophrenia-associated regions. Using advanced methods, they then identified 120 genes that would potentially be linked to the disorder.
Although there are a large number of genetic variants involved in schizophrenia, the research revealed that genes expressed in neurons are likely to be the most important therapy point. These findings also suggest that abnormal neuron function in schizophrenia can affect many brain areas, which might explain its diverse symptoms, including hallucinations, delusions, and difficulties thinking clearly.
Researchers claim that genetic testing has enabled individuals to benefit beyond those of European descent.
According to Dr. Fanous, we must use the power of vaster, more ethnically diverse datasets to assist people of all ages in developing genetic investigations and to educate people about these problems.
More than half of Americans will be diagnosed with a mental illness or disorder at some stage in their lives, according to statistics from the Centers for Disease Control and Prevention. A serious mental illness, such as schizophrenia, affects one out of 25 people.
According to Guy Reed, the University of Arizona''s translational research community in neuroscience and mental health is empowering people in Arizona. Dr. Fanous is a pioneer in scientific development in genetics and genomics, in partnership with the Phoenix VA Health Care System, and is looking for new therapies that will provide personalized care to patients.
This global study, led by Cardiff University, is giving the most exposure to schizophrenia''s genetic basis.