In Atherosclerosis, diseased blood vessels may connect with the brain

In Atherosclerosis, diseased blood vessels may connect with the brain ...

For the first time, LMU scientists have been able to demonstrate that nerve signals are exchanged between arteries and the brain in atherosclerosis.

Laboratoriies across the globe are conducting research on the illness atherosclerosis. However, their focus is on cholesterol, fibrous tissue, and immune cells that form on the inner layer of arteries. These plaques gradually restrict the lumen of the arteries, enabling less oxygen to reach the body tissue. Heart attacks, strokes, and peripheral occlusive disease (smokers leg) are among the known implications.

No one has ever wondered if atherosclerotic plaques are inferred between the artery and the brain, according to Dr. Sarajo K. Mohanta of the LMU Institute for Cardiovascular Prevention. But this is precisely because he has now demonstrated withProfessor Andreas Habenicht, also of the LMU Institute for Cardiovascular Prevention, and an international team. Crucial results were obtained by Professor Daniela Carnevale and Professor Giuseppe Lembo from the University of Rome''s Cluster of

InNature, the researchers reveal their findings about signals that are transmitted from the arteries containing plaques via nerves to the brain. Once the processing of the signals in the brain has begun, signals make their way back to the blood vessel.

A complete overhaul of atherosclerosis.

Background information: The arterial walls are made up of three components: an outer layer, a middle layer, and an inner layer. Plaques are discovered in the inner layer. This fact has long been known. It was not unusual to anyone to investigate whether the peripheral nervous system comes into contact with arteries in the case of atherosclerosis, according to Habenicht.

Since 2004, his research group has been working on what happens on the outer wall of arteries in patients who have suffered with atherosclerosis. After all, atherosclerosis is rather a plaque, but it is a chronic inflammation of the whole artery, and relevant to our findings, according to Mohanta, who is the head scientist in charge of the project.

Molecular sensors known as receptors have a large role in the formation of plaques and where vessels are inflamed, then they identify the inflammatory messengers of the inflammation. This affects inflammation, and the atherosclerosis worsens.

Long-term possibilities for the treatment of atherosclerosis causes

This previously unknown electrical connection between the arteries and the brain is of huge significance. Carnevale severed the electrical connection between a diseased artery and the brain in an animal experiment. Eight months later, she compared treated mice with those who had not had this procedure. In the experiments, Atherosclerosis was in fact less developed than in control mice. However, we hope to be finally able to deal with the causes of atherosclerosis in the long run, although it may well be a long run.

The scientists hope to study how the peripheral nervous system is organized and how other receptors play. There are also many indications that stress is regulating the interface between the brain and diseased blood vessels. Consequently, Habenicht is planning to investigate neurobiological aspects: Which cells in the brain respond to diseased blood vessels? Exactly, with which regions of the brain are these cells connected in turn?

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