Stimulation of a high-frequency spinal cord shows off a boost to pain relief

Stimulation of a high-frequency spinal cord shows off a boost to pain relief ...

The process of spinal cord stimulation (SCS) for chronic pain involves sending low levels of electricity directly into the spinal cord, which prevents or stops nerve activity in order to decrease the sensation of pain reaching the brain. This approach is most often used after nonsurgical pain treatment methods have failed to provide adequate relief.

The fundamental mechanisms of how SCS works are not fully understood, but in a new paper published in the journalBioelectronic Medicine on April 28, 2022, a research team based at the University of California San Diego School of Medicine has found that high-frequency SCS has significantly improved perceived pain reduction (PPR) than low-frequency SCS in patients who have been tested, and that there was some variation in PPR between male and female patients.

In 1989, the FDA approved high-frequency SCS (10,000 Hz) that stimulates electrical stimulation pulses that are shorter in length, lower in amplitude and do not induce paresthesia. Even the abnormal sensation of tingling or prickling has prompted the FDA to approve high-frequency SCS.

94 patients (40 females, 54 males) who received HF-SCS, and 143 patients (70 females and 73 males) who received LF-SCS, according to the newly published retrospective study. PPR across all patients improved after three and six months post-implantation, but HF-SCS produced higher PPR than LF-SCS. HF-SCS was also associated with reduced subsequent use of opioids to relieve pain.

Despite these findings, there were differences between the two men.

  • Male PPR, for example, was significantly better for HF-SCS at three and six months when compared to LF-SCS, while this was only true for females at the 6 month time point.
  • LF-SCS males used more opioids post-implantation and at six months while females used more opioids post-implantation, at three, six and tended to use more opiates at the 12-month time-point.

Selon a growing author, sex specific immune pathways may differentially contribute to chronic pain procedures. Currently, there are some parameters that are known as sex differences in spinal cord stimulation efficacy and opiate use.

It''s a first step in the direction, but more work needs to be done to ensure that sex specific pain regulatory mechanisms are carefully outlined, indicating that their potential effects might be limited to specific types of neuromodulation and pharmaceutical therapies.

All of them at UC San Diego, Rosalynn R.Z. Conic, Zabrina Reyes, and Sopyda Yin, both authors, are also members of the Pacific Western University of Health Sciences. Jacob Caylor, UC San Diego and Northwest Pain Care, Spokane, WA, Christina L. Cui, Duke University, and Eric Nelson are among the authors.

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