Severe COVID-19 is identified as a viral response path

Severe COVID-19 is identified as a viral response path ...

Researchers in Yale have identified a certain immune response method that can lead to severe illness and death among individuals infected with the SARS-CoV-2 virus.

The study was published in the journal Nature on April 28.

Researchers have discovered that once the COVID-19 virus infects the lungs, it can form a cytokine storm or an overactive immune response that causes deadly inflammation in the lungs. For the next research, a Yale team led by Esen Sefik, senior author ofRichard Flavell, studied the effects of the SARS-CoV-2 infection in mice that are engineered to have a human immune system.

Inflammasomes, an immune system early warning system, produce and release cytokines which lead these immune cells to commit suicide in an attempt to prevent infection. However, these cytokines also recruit even more inflammatory cells to the lungs from the blood, which leads to pneumonia.

It''s like a broadcast system, but in this case the message is lethal, according to Flavell, Sterling''s Professor of Immunobiology and investigator at the Howard Hughes Medical Institute.

Researchers found that using the NLPR3 inflammasome pathway, infected mice were rescued from pneumonia. Its failure was yet to be triggered by the inflammation mechanism. But they were no longer inflammatory and therefore could. cause damage to the cells.

One additional benefit of this treatment is that the cells no longer die and release additional viruses. Nevertheless, a blockade of the inflammasome pathway along with antiviral therapy might bolster the chances of treating COVID-19 pneumonia and preventing severe COVID-19 symptoms, according to researchers.

Although there are no approved medications that prevent the NLPR3 pathway, many pharmaceutical and biotech companies are developing them, according to Flavell.

The Howard Hughes Medical Institute has funded the research.

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