Team proposes a new carrier to provide chemotherapy drugs

Team proposes a new carrier to provide chemotherapy drugs ...

Polyoxometallate nanoclusters have been proposed as a substrate for a chemotherapy drug. It will be used directly to the focus of a pathological process, such as a cancerous tumor, without harmful effects on healthy cells. Delivery can be accomplished either by electrophoresis or by injection into the bloodstream.The development isdescribed in theAIP Conference Proceedings.

molybdenum polyoxometalates are formed of molybdenum and iron, containing common oxygen atoms, and containing organic groups. Their peculiarity is that they are a nanocluster to the surface of which a medication can be attached and delivered to the tumor formation. However, these polyoxometallates do not affect living cells and do not affect their function or morphology. According to Dr. Moritzo, the university of Wisconsin has pioneered the development of molyb

Futher scientists envision to attach a vector molecule to the polyoxometallate''s surface that can distinguish cancer cells and ensure the binding of the nanocluster to them, avoiding healthy ones.

Scientists sag how the nanocluster would interact with doxorubicin. This anticancer antibiotic is well-known in terms of destroying tumor structures, but has low selectivity. High concentrations of the medication needed to destroy cancer cells are harmful to the weakened body.

The unquestionable advantage of targeted delivery is the possibility to modify the medication dosage. Our research has shown that a too high concentration of doxorubicin in a polyoxometallate capsule will also result in the death of healthy cells: the container will not be able to keep active substances from entering DNA through the nuclear and cell membranes, according to UrFU''s head.

Biochemistry and research have begun on cervical cancer cell structures (carcinoma) and this technique of delivery can be applied to other tumors in the future. During the next phase of the study, scientists will conduct preclinical analyses on laboratory animals to assess the therapeutic effectiveness and safety of the system. These authors note that nanocluster compounds will be able to deliver other medications, such as anti-inflammatory ones. The developed technique will help to improve the accuracy of targeted medication delivery.

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