The Lipid Nanoparticles' High-Resolution View

The Lipid Nanoparticles' High-Resolution View ...

Lipid nanoparticles (LNP) are used to effectively protect and transport mRNA to target cells in mRNA-based vaccines and therapies. To ensure the quality and safety of LNP, lipid components and their metabolites must be carefully identified and quantified in raw materials and formulation. The lipids and their metabolites must be identified and quantified in order to understand their distribution, clearance, and biodegradation pathways in the body. Download this app note to learn:

  • Confident LNP component confirmation using HRAM MS and MS/MS data
  • Confident identification of low abundant lipid impurities and degradants at <0.1% in LNP formulations
  • Simultaneous lipid quantification and unknown metabolite identification with LOD of 0.1ng/mL in complex biological matrices

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