AMSBIO examines how research conducted at the Washington University School of Medicine (St. Louis, USA) using their 10E4 Heparan Sulfate antibody to investigate obesity to investigate the role of HS in the process of intercellular mitochondria transfer to macrophages.
According to recent research, adipose-tissue resident macrophages acquire mitochondria from adjacent adipocytes usingHS. This process is in healthy environments but it is affecting obesity. Further, they have demonstrated that intercellular mitochondria transfer to macrophages mediated systemic metabolic homeostasis.
Obesity is a metabolic disorder that affects over 40% of adults and 18% of children and adolescents in the United States, and it is an independent risk factor for the development of many other diseases, such as type 2 diabetes, cardiovascular diseases, and cancer.
Professor Jonathan Brestoffcommented Mitochondria are the power plants of cells, and it has been long assumed that they are made in one cell and never leave. We identified that this is not the case, and found that fat cells transfer their mitochondria to an immune cell type called macrophages. This is causing an increase in weight gain, and thus, the whole genome is examined and examined. This suggests that cells may be able to use this technique to treat human diseases.
Wentong Jia, a postdoctoral researcher at the Brestoff lab, said the cell surface expression of heparan sulfate, a glycosaminoglycan required for mitochondria uptake in macrophages, is dependent on an important glycosyltransferase named EXT1. The 10E4 antibody from AMSBIO has helped us verify that Heparan Sulfate has successfully been prevented from being synthesized in cells that have no EX
According to Rocky Giwa, a PhD candidate in the Brestoff Lab, it is fascinating that cells use heparan sulfates to take up mitochondria. I wonder if there''s a connection between the amount or composition of the heparan sulfates and the ability to efficiently take up mitochondria from other organisms. Since the various HS antibodies have specificities, the different clones can assist us begin to address that problem.
AMSBIO offers a wide range of high-quality Heparan Sulfate antibodies from F69-3G10, F58-10E4 and JM403 clones, ideal for targeted binding of HS in Heparan Sulfate Proteoglycans (HSPG).
Heparan sulfate is a highly sulfatedpolysaccharide, which is widely distributed on cell surfaces and basement membranes in mammals. It is part of important biological processes because to its excellent communication with many biologically active proteins. AMSBIO is a leading supplier of high-quality Heparan Sulfate antibodies from the clens (JM403, 10E4 and 3G10), which are ideal tools for investigating the binding of HS in several areas of biological