A Very Deep Cell Atlas of the Fallopian Tube Has Been Created

A Very Deep Cell Atlas of the Fallopian Tube Has Been Created ...

The fallopian tube is the subject of fertilization, where once a month for the duration of a females post-pubescent and post-menopausal life, an egg is moved from the ovary, ready for fertilization by a sperm cell.

A new study from Michigan Medicine researchers has created a "atlas" of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for further research into infertility and other illnesses affecting this organ, including some cancers.

A team at U-M in a research using tissue samples from four premenopausal women, led by Saher Sue Hammoud, Ph.D., andJun Li, Ph.D. from the Department of Human Genetics. The study investigated almost 60,000 cells in a single-cell RNA sequencing. These findings characterized the diversity of cells that form the fallopian tube, including both the lining of the tube (the epithelium) and the deeper stromal layer, which includes

Ariella Shikanov, Ph.D., of the Department of Biomedical Engineering,Erica Marsh, M.D., of the Department of Obstetrics and Gynecology, and team membersNicole Ulrich, M.D., Yiu-chi Shen, Ph.D., and Qianyi Ma, Ph.D. Their project is part of the Human Cell Atlas Seed Networks, an international initiative supported by the Chan-Zuckerberg initiative to map all cells in the

According to Hammoud, prior to their research, there were around four epithelial cell types in the fallopian tube. We were able to discern a deeper level of heterogeneity within these cells.

Ten epithelial cell subtypes have been identified, including four of the finger-like ciliated cells responsible for transferring the egg through the fallopian tubes three sections before and after fertilization.

The cells in the fallopian tube are constantly changing, reducing themselves over time and varying depending on a woman''s age, hormonal, menstrual cycle, and the possibility of illness. Using a combination of samples from women with a healthy fallopian tube, researchers were able to identify which cells increased in number, and which altered characteristics.

Some cells are the causes of the disease state, and others are the consequence; now we know the patterns for individual cells to investigate the molecular reasons for that pathology, according to Li.

Is there any connection between precursor cells in the tube and cancer?

The team found that some of the fallopian tube cell subtypes may be a precursor cells, those that can regenerate multiple cell types in response to normal tissue turnover, or for repairing a damage.

According to Hammoud, the discovery of cells with markers for epithelial-mesenchymal transition, also known as EMT, a process previously associated with the fallopian tube, through which a cell can, under certain circumstances, become cancerous.

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According to a pre-menopausal woman, the EMT process appears to be regulated rapidly in this population of cells, including those who have suffered from ovarian cancer. With EMT cells in the fallopian tube, you have the right predisposition.

Additional evidence from hydrosalpinx''s fallopian tube cells suggests that the disease might lead to a type of scarring called fibrosis. For women who do not want their tubes removed, you may opt to treat them with anti-fibrotic medications such as those prescribed to treat lung fibrosis as a way to save their tubes during reproductive age, according to Hammoud.

This is really a basecamp to begin future research, according to Li, focusing on age, the menstrual cycle, hormone therapy, and the ancestral background on cell diversity and disease pathology.

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