Using this tool, you can experience cellular traffic and internalization of drugs

Using this tool, you can experience cellular traffic and internalization of drugs ...

As hormones - or chemical messengers - bind to cell membrane receptors to fine-tune how the cell behaves, inside your body, a metaphorical communication and traffic network is underway. This hormone-receptor complex begins by ferrying chemical signals from outside the cell and then transforming them into action inside the cell. The process of moving into the cell is called trafficking.

For the first time, new technologies at the University of Houston College of Pharmacy will be able to look inside and take a look at the trafficking in real-time. Bradley McConnell, a professor of pharmacology, has developed a technique to identify membrane protein trafficking as a result of bioluminescence, the production and emission of light inside living organisms, removing the need for costly protocols, methods, or highly automated equipment.

The primary author of the papers is Arfaxad Reyes-Alcaraz, a postdoctoral fellow at McConnell''s laboratory. This technique can be applied to monitoring the effectiveness of a potential new therapeutic medication that is targeted to a cell receptor and then internalized into the cell. It can also be used to detect the SARS-CoV-2 viral entry into the cell.

The authors anticipate that the treatment for heart disease, metabolic disorders, cancer, infectious diseases, COVID-19, and others will be used.

The process detects how cell receptors are internalized into the cell as part of their normal function in response to a hormone or a therapeutic medication, resulting in an increase in the ability to understand how the body works. This process has been successfully investigated by scientists for years by using complex and expensive biological tools, but significant and versatile techniques have failed to investigate such processes in real-time living systems.

Imagine now putting this process together in a way that is even more efficient than it is currently available. If the membrane receptor is in the early endosome to monitor receptor internalization, then it may be done quickly and inexpensively.

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