NanoGenizer, a lab-scale microfluidic high pressure homogenizer, has demonstrated exceptional performance on particle size reduction and cell disruption. It is equipped with highly powerful cross-functional power and processing equipment. It is great for rare and valuable samples because of its low dead volume design and its continuous flow rate, which allows it to process up to 120 mL/min. With successful applications in various nanotechnology settings, the NanoGenizer has gained more recognition thanks to its remarkable shear rate, excellent repeatability, and guaranteed s
NanoGenizer offers innovative solutions for a wide spectrum of nanomaterials, including liposomes, nano-emulsions, micelles, lipid nanoparticles, cosmetic nano-encapsulation materials, nano-particle dispersion, graphene, carbon nanotube, and more. NanoGenizer is becoming an essential high-pressure homogenizer for high-end nanomaterial preparations.
Figure 1. NanoGenizer Microfluidic jet high pressure homogenizer
The microfluidic diamond interaction chamber, including the power system, and the high-pressure pump, is divided into two components, each with a special-designed fix geometry. After being pressurized and accelerated by the intensifier, the samples micro-jet can reach 1,000 m/s, faster than the speed of sound (340 m/s). The material is then homogenized and nano-sized.
The diamond interaction chamber is the core area where the high-speed micro-jet, high-shear, high-energy collision and other effects are observed. It has fixed Y- or Z-shaped diamond micro-channels inside, which ensures a consistent effect: accurate and repeatable particle size distribution.
Figure 2. The DIXC''s internal structure
Figure 3. Interaction chamber with cooling system with single-slotted
The NanoGenizer High Pressure Homogenizer Features
The liquid or solid-liquid mixture samples micro-jet may reach speeds up to 1,000 m/s inside the diamond interaction chamber (DIXC) as shown in Figure 4, the NanoGenizers shear rate is the highest among comparable technologies.
Figure 4. Hear rates of comparable homogenizing techniques
Traditional homogenizers or other homogenizing equipment are the same for the NanoGenizer high pressure homogenizers.
Figure 5. Microfluidic diamond interaction chamber with a single-slotted Y-type
Figure 6. Microfluidic diamond interaction chamber of a single-slotted Z-type
The diamond interaction chamber has a fixed internal shape (Figures 5 and 6) and does not move with pressure changes. However, the traditional homogenizing valve requires a dynamically adjustable structure. When the sample passes through the DIXC, the applied pressure is at an all-time high during each cycles process, according to the blue curve in Figure 7). The particle size of the material used in the microfluidic diamond interaction chamber is reduced effectively, and the distribution is more uniform than it is possible with a conventional homogenizing valve
Figure 7. Pressure curve wahrend homogenization process
The Y-type DIXC enhances the interaction between the materials themselves and has a double the relative velocity of the two jets, resulting in an explosion effect. The collision between the materials greatly reduces the materials'' wear and shear to the interaction chamber, prolonging the service life of the chambers, and avoiding the possibility of stainless steel particles falling off. The patented DIXC-RT, which has a cooling function (see Figure 3) is effective in protecting the bioactivity of samples.
Figure 8. Microfluidic diamond interaction chamber with multi-slotted Y type
Figure 9. Microfluidic diamond interaction chamber of multi-slotted Z
The single-slotted DIXC (shown in Figure 2 and Figure 3) is suitable for lab-scale high pressure homogenization equipment. The multi-slotted DIXC (shown in Figure 8 and Figure 9) is composed of multiple diamond micro-channels in parallel, ensuring the treatment effects consistency. The increased number of channels also allows for a higher volumetric flow rate.
Genizer LLC is one of two corporations in the world that provides high-pressure homogenizers equipped with the original microfluidic diamond interaction chambers. In recent years, Genizers has expanded its microfluidic diamond interaction chambers.
The NanoGenizer high-pressure operation is very straightforward to install and operate. Operators can complete routine operations by clicking the three buttons "pressure rate, start, and stop on the touch screen. Customers find the equipment simple to operate: they only need to press the pressure on the screen and then click to start or stop. There is no need to screw the sample volume directly, according to the stroke cycle times. The NanoGenizers operation is elegant and effective.
Figure 10. NanoGenizer''s operation interface
The high-efficiency NanoGenizers modular pipeline design allows for easy installation and maintenance. The dead volume is no more than one liter above the dead volume of other high-pressure homogenizers, which is usually less than 10 mL. Therefore, when a 10 mL sample is processed autonomously, making it the best equipment option for preparation and manufacturing rare, costly samples. NanoGenizer''s continuous flow rate is 7 L/h, suitable for conventional small batches.
Jacketed interaction chamber; jacketed inlet cylinder; 3D heat exchanger
Preparation for Suspension: A hollow magnetic stirrer
Titanium cylinder option for Corrosion Resistance
Precision sampling is as exact as 0.1 million pounds (e.g., 10.0 millionL, 10.1 millionL, and 10.2 million l sampling are all possible).
Ports: Data Log, USB Port, and Multi-sensor ports for temperature and pressure
Scientific researchers who have used NanoGenizer are impressed by its high processing efficiency, easy operation, and effective control. NanoGenizer is currently the world''s most popular homogenizers.
Figure 11. NanoGenizer''s Applications in Nanomaterials