According to a new study, a ketogenic diet that is low in carbohydrates and protein, but high in protein, helps to kill pancreatic cancer cells when combined with a triple-drug therapy developed by theTranslational Genomics Research Institute (TGen), a group of Hope.
In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting that the diet helped suppress the cancer. Moreover, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells.
According to the study, the ketogenic diet sparked a microenvironment in which the triple-drug therapy developed by TGen a combination of gemcitabine, nab-paclitaxel, and cisplatin was more effective in disseminating the tumor.
By restricting glucose availability, the ketogenic diet may promote chemotherapy efficacy, according to TGen Distinguished ProfessorDaniel D. Von Hoff, the doctor, who is considered one of the world''s foremost authorities on pancreatic cancer. Dr. Von Hoff is one of the researcher''s authors and designers.
By boosting pro-inflammatory tumor expression, the ketogenic diet proved to have a beneficial effect on antitumor immunity.
Clinical trials at five locations
Researchers conducted a clinical trial of up to 40 patients at five locations across the country: HonorHealth in Scottsdale, USC in Los Angeles, Nuvance Health in Connecticut, Atlantic Health System in New Jersey, and South Texas Accelerated Research Therapeutics in San Antonio.
The clinical trial will determine whether using a ketogenic diet to the triple-drug therapy will increase overall survival in pancreatic patients. This clinical trial has begun in late 2020 and is expected to continue to expand until June 2023. Patients will be randomly assigned to either receive the triple-drug regimen while on a standard diet, while the other half will receive a ketogenic diet and the triple-drug therapy. The dietary aspects of the study are being carefully monitored.
According to a researcher and one of the researchers, a ketogenic diet alters pancreatic cancer metabolism and its response to chemotherapy.