When children receive the Coronavirus, the RS Virus, and the Rhinovirus, it has an interesting effect

When children receive the Coronavirus, the RS Virus, and the Rhinovirus, it has an interesting effec ...

Inger Heimdal was beginning to study the coronavirus in children in 2014, but few observers considered the topic as particularly motivating.

Coronavirus was considered quite harmless and of little interest to research. That has, for the first time, changed.

The novel coronavirus SARS-CoV-2 has ravaged tens of thousands of people around the world. Some scientists believe that the virus will mutate towards less harmful variants.

NTNU, a Norwegian university of science and technology candidate, has agreed to do so.

In the beginning of my research, there were four corona varieties that were not considered particularly harmful. Perhaps SARS-CoV-2 will become a new member of this group. In the case, it would be really beneficial to acquire more knowledge about the four older coronavirus variants. According to Heimdal, a large amount of this knowledge may be transferred to SARS-CoV-2 in the near future.

Heimdal is enrolling in her doctorate in coronavirus infections in children who were taken to St. Olavs Hospital in Trondheim for acute respiratory disease in the period 2006-2017.

Few cases but resource intensive

Researchers found 341 cases (8 percent) with the coronavirus among 4312 children with respiratory infections hospitalized during the twelve-year study period.

Despite the vast majority of people becoming only mildly ill with the common coronavirus symptoms, a few patients are extremely ill and require breathing treatment.

The risk for children who had a coronavirus and respiratory syncytial (RS) virus was twice as high, as for those who only contracted the RS virus.

Patients who are seriously ill have to stay in the hospital for a long time. This requires significant resources from the health care system. We must educate ourselves more about the health consequences that the coronavirus has borne in order to prepare for health treatment in the future, according to Heimdal.

One difficulty in assessing the coronavirus''s disease burden is that it often occurs in tandem with other respiratory viruses.

In 70% of cases, NTNU researchers found other co-occurring viruses, mostly the RS virus and rhinovirus. RS may cause pneumonia in young children, while the cold virus rhinovirus is considered a milder virus.

RS virus is more severe

When Heimdal and her colleagues compared the different respiratory viruses, they discovered something interesting. Among the children who only had the coronavirus, one in five developed a serious respiratory infection and required intensive medical treatment.

I believe that young children''s parents have more reason to be concerned about the RS virus than corona.

For children who contracted the coronavirus or the RS virus, the risk of serious illness sounded twice as large as the number of people who contracted the virus. Forty percent of these children had a severe onset of the disease.

My parents of young children have more reason to be concerned about the RS virus than coronavirus. In our approach, we see that the RS virus causes hospital admissions significantly more often, and among those admitted, a much greater proportion develop a serious disease course.

Is it beneficial to have additional viruses?

The more viruses there are, the worse the disease. However, Heimdal found that the proportion of serious illness among children who had both corona and rhinovirus was significantly reduced than for those who had only corona.

Is it an advantage to contract both the rhinovirus and the coronavirus?

Both viruses appear to be beneficial, but I must be clear that our model only allows us to investigate associations. We cannot establish a clear causal link, according to Heimdal.

While it might deduce other viruses, inflicting a potentially harmful virus on a patient isn''t ethically justified. However, it is also beneficial to see what it takes to deduce the disease.

Perhaps the rhinovirus has triggered the immune system to be more at the forefront in order to effectively treat potentially harmful viruses. Hopefully, research can help us figure out what is happening so it can be beneficial in treatment, according to the author.

Cell cultures have previously shown that rhinovirus has a similar effect on SARS-CoV-2, but this is the first time the effect has been detected in patients.

Viruses are constantly changing, but it is rare for this to say so often.

There is less room for new variants right now that the population is beginning to become so well immunized. Viruses change constantly, but it is very rare for many people to come of it. The coronavirus is also inherently limited in what it can offer.

Overall, the degree of immunization in the population is more important than which variant has regained the most recognition, according to her.

SARS-CoV-2 may be similar to other coronavirus variants, according to Heimdal. This means that a large majority of children will be infected annually, but the vast majority will only experience a mild cold.

A handful of kids might have severe enough symptoms to require being hospitalized, but they are generally insignificantly reduced numbers than the RS virus and rhinovirus.

The PhD candidate''s perspective is that the RS virus will likely fall behind the SARS-CoV-2, while the combination of coronavirus and rhinovirus may conceivably cause milder symptoms.

Heimdal''s research is part of the respiratory projectChildhood Airway Infection Research Groupin the Childrens Clinic, the Department of Medical Microbiology at St. Olavs Hospital, and the NTNUs Department of Clinical and Molecular Medicine.

Coronavirus history

The first time the coronavirus was discovered in humans was in the 1960s, when two different viruses were identified. In China, a new and dangerous coronavirus SARS-CoV spread out, and the virus appears to have disappeared. In the wake of the SARS epidemic, two additional coronaviruses were detected.

In 2012, MERS-CoV, the sixth version, appeared in the Middle East, but the disease may be fatal, although it has not spread outside the Middle East.

In 2019, the seventh coronavirus, known as SARS-CoV-2, and the resulting disease COVID-19, have been diagnosed.

The "descendants" of previous pandemics that recur with the four common coronaviruses year after year are. Nobody knows for sure when the outbreak started. According to Heimdal, the Russian flu in 1889 might have been a coronavirus epidemic.

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