New Clues for Parkinson's Treatment Have Been Clued in Genetic Research

New Clues for Parkinson's Treatment Have Been Clued in Genetic Research ...

With the publication of groundbreaking genetic research from the University of Auckland, New Zealand, there''s fresh hope for reducing Parkinson''s disease.

A research team has been led by Professor Justin OSullivan of the Universitys Liggins Institute and Professor Antony Cooper of the Garvan Institute of Medical Research.

In a paper published in the journalBrain, the research team examined 90 known genetic modifications that are each individually related to the risk of developing Parkinsons disease and demonstrated how they affect biological pathways in the bodys tissues, many far from the brain. Nine of these pathways, some of which have never been linked to Parkinsons, seem to be critical.

Justin believes that our ultimate goal is to reduce or stop Parkinsons. If we can understand how genetic changes work together to mitigate the likelihood of developing the disease, weve got the advantage.

People will be able to receive treatment for the exact type of Parkinsons they have or are at risk of developing. Were working for that day to come as soon as it can, according to Dr. Mark Holtz.

These findings help scientists understand the potential of genetic risk factors for developing Parkinsons disease.

Our aim is to identify which of the 90 genetic modifications interfactor certain combinations that block a biological pathway and thus contribute to an individual developing a disease subtype, according to Antony. This paper is a fundamental first step (to accomplish that goal).

Sophie Farrow participated in a follow-up study funded by the Michael J. Fox Foundation for Parkinsons Research. Sophie is now moving from computer to laboratory work on human cells to test the team theory and prove that genetic variations have the effect they have identified.

The teams findings, according to a top journal on Parkinsons and dementia in August 2020, were presented as a cover story. After they demonstrate that genetic changes in a gene called GBA play a role in regulating the duration of the disease.

One of the most recent findings from teams (published inFrontiers in Geneticsin 2022) suggest that changes within a part of the heart called an atrial appendage might aid people developing Parkinsons.

Parkinsons was once seen solely as a brain ailment, but now we know it much, much more, according to Justin.

Despite the number of people it affects, Parkinsons remains a medical condition.

Doctors do not know why many people develop the disease, and there is no cure.

Parkinsons affects about 10 million people worldwide, with one-in-one people over the age of 60 in New Zealand suffering from it, including tremor, rigidity, fatigue, bladder and bowel problems, depression, and sweating.

Grants from The Michael J. Fox Foundation for Parkinsons Research, the Silverstein Foundation for Parkinsons with GBA, and The Dines Family Foundation have helped them.

According to Justin, Parkinsons isn''t just one disease; it''s a disease that has many different sub-types, depending on the ranges of genetic changes.

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