How Gene Networks Regulate the Risk of Parkinson's

How Gene Networks Regulate the Risk of Parkinson's ...

With the publication of groundbreaking genetic research from the University of Auckland, New Zealand, there is new hope for treating Parkinsons disease.

A research team is authored by Professor Justin OSullivan of the University of Michigan and Professor Antony Cooper of the Garvan Institute of Medical Research.

In a study published in the journalBrain, the research team examined 90 known genetic changes that each individually had a connection with the risk of developing Parkinsons disease, and demonstrated how they affect biological pathways in the body''s tissues, many far from the brain. Nine of these pathways, some of which have previously been linked to Parkinsons, appear to be crucial.

According to Justin, our ultimate goal is to alleviate or eliminate Parkinsons. If we can understand how genetic modifications work together to reduce the risk of developing the disease, we have got a shot at doing it.

Eventually, personalized medicine will enable people to be treated for the exact type of Parkinsons they have or are infected with. He believes he is working hard for that day to come as quickly as possible.

The findings help scientists understand the importance of genetic risk factors for developing Parkinsons disease.

This paper is a critical first step (to meet that objective).

Sophie Farrow applied for a postgraduate degree in neuroscience. She is now moving from computer to lab work on human cells to test the team''s theory and prove the genetic variations have the effect they have identified.

The findings from the prestigious journal on Parkinsons and dementia were presented as a cover story in August 2020, when they discovered that genetic changes in a gene called GBA play a crucial role in regulating the duration of the disease.

One of the most recent findings from the teams (published inFrontiers in Geneticsin 2022) suggest that changes within a portion of the heart called an atrial appendage might assist people with Parkinsons.

Parkinsons was once thought to be a brain disease, but now we know it much more than it, according to Justin.

Despite the number of people it affects, Parkinsons remains a medical concern.

Doctors do not know why most people develop the disease, but there is no cure.

Worldwide, more than 10 million people have Parkinsons, and one in every 100 people over the age of 60 in New Zealand have the disease, ranging from tremor, rigidity, fatigue, bladder and bowel difficulties, depression, and sweating.

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