A pathogen and medicine team is working to combat fungal Lung Infection

A pathogen and medicine team is working to combat fungal Lung Infection ...

Pathogens do not always work against drugs, and they may, according to a fresh study from the University of Maine.

Diseases caused by a combination of bacteria, viruses, fungi, and parasites, also known as polymicrobial infections, are difficult to treat, because scientists cannot comprehend how pathogens interact during infection and how these interactions impact the medications used to treat them.

Researchers in the Molecular and Biomedical Sciences Department conducted an analysis of two pathogens that occur at similar sites, particularly in cystic fibrosis and mechanically ventilated patients:Candida albicansandPseudomonas aeruginosa.

Candidais is the fourth most common hospital-acquired pathogen, and is particularly difficult to treat. Despite its effectiveness, several antifungal agents slow it rather than kill it outright. In total,P. albicansandP. aeruginosainfects 90% of adult cystic fibrosis patients.

The researchers examined the effectiveness of an antifungal medication, fluconazole, in the test tube, and during the infection of the zebrafish. Although fluconazole is known to slow fungal growth,Candidacan is recognized to be sensitive to the medication and not only survive, but develops tolerance that leads to bad therapy and, potentially, death.

What the study found was valuable. The results showed thatP. aeruginosa works with fluconazole to eliminate drug tolerance and clear theC. albicansinfection in the culture and the zebrafish.

Polymicrobial infections are difficult to treat non only because of the lack of knowledge about how invading microorganisms interact, but also because we cannot comprehend how these interactions influence treatment effectiveness. According to Siham Hattab, the lead author of the study who conducted the research as part of her Ph.D. in the Department of Molecular and Biomolecular Sciences, polymicrobial interactions are effective in treating human beings.

The bacteria increases the drug''s capacity against a second pathogenicCandidaspecies, which is usually more resistant to the drug.

The increased effectiveness of the drug suggests to the researchers that there is still much to learn about when it comes to addressing these dangerous and complex polymicrobial infections.

In a more real-world environment, medication anti-fungal drugs can work even better than in the test tube, according to Robert Wheeler, an associate professor in microbiology and senior author.

You may also like: