Spider Silk is used to stabilize cancer-suppressing protein p53

Spider Silk is used to stabilize cancer-suppressing protein p53 ...

The p53 protein protects our cells from cancer and is an excellent treatment strategy. However, the protein is more stable and effective in the treatment of cancer. This research has shown that it is possible to develop a spider silk protein that is more efficient and capable of killing cancer cells. The researchers at Karolinska Institutet have studied the concept of p53, which is therefore a way to understand the nature of the process.

Inspired by nature

According to one expert, cells make relatively large amounts of p53 and then break it down as it is a very large and disordered protein. Weve been inspired by how nature has established stable proteins and have applied spider silk as a substitute for other nature''s strongest polymers. Using electron microscopy, computer simulations, and mass spectrometry, the researchers found that this technique was beneficial to the formation of p53s disordered sections.

Hope to develop a cancer vaccine

The researchers hope to uncover how the proteins structure is being studied in depth and how its various components interact in order to prevent cancer. A study will begin soon on how the cells are affected by the new powerful p53 protein, and how well they tolerate its spider-silk component.

The goal of reimagining a more stable version of p53 in cells is to improve cancer treatment, and so we can now develop a therapeutic environment that is worth exploring. During this period, researchers at the Karolinska Institutet, the Swedish Cancer Society, the Swedish Research Council, Vinnova, the Olle Engkvist Foundation, the Swedish Medical Research Foundation, Formas, and the Ake Wiberg Foundation have received grants.

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