A collaborationd research team led by Prof. WANG Hui from the High Magnetic Field Laboratory, the Chinese Academy of Sciences (HFIPS) described the synthesis of hollow cuprous oxide@nitrogen-doped carbon (HCONC) by a one-step hydrothermal method as well as their use in efficient chemodynamic therapy.
Due to its low invasiveness and high selectivity, chemodynamic therapy (CDT) has received extensive attention. Among various metal-based nanocatalysts, the low redox potential of Cu+/Cu2+in cuprous-based nanocatalysts has significantly reduced renal function (ROS) yields and reduced glutathione (GSH) overexpression, which can be shown as a Fenton-like agent in relatively tight environments. Therefore, it is necessary to develop
For catalyzing the cascade reaction and improving the effectiveness of CDT, researchers used a one-step hydrothermal technique to synthesize HCONC nanocapsules. This "nanocapsules" consist of nanoparticles is not "capsules" in the traditional sense. It is a core-shell structure formed by ingeniously attaching a thin layer of carbon to the surface of hollow cuprous oxide (Cu2O) nanocrystals, which non only prevents
The Cu+-mediated Fenton-like reaction in HCONC is effective in catalyzing H2O2to produce OH, and the Cu+released in the TME is capable of decomposing overexpressed GSH to preserve the nascent ROS.
Both in vitro and in vivo experiments demonstrate that HCONC has an excellent antitumor capability without causing systemic toxicity. "The whole process can be described in a painful saying," said Prof. WANG.