Researchers at the Department of Chemistry and the Department of Astronomy at the University of California, Irvine, presented new information about a key enzyme that makes DNA sequencing possible. This breakthrough is a journey forward into personalized medicine when doctors will be able to design therapies based on individual patients'' genomes.
Enzymes make life easier by catalyzing chemical changes that otherwise would be too long for an organism, according to Greg Weiss, an UCI professor of chemistry and a co-author of the new study. One of the transformations that we were really interested in is that, for all human beings, the process by which DNA is copied and repaired.
Taq, a substance used by the UCI-led team in the United Arab Emirates, is a synthetic substance used by the UCI group to develop and develop a novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel novel
Taq, as it helps make new DNA copies, behaves completely like those previously thought. Instead of behaving like a well-oiled, efficient machine continuously churning out DNA copies, weiss explained, the enzyme acts like a indiscriminate shopper who walks the aisles of a store, tossed everything they see into the shopping cart.
Instead of selecting one piece to add to the DNA chain, the enzyme collects dozens of bugs for each piece added successfully. Like a shopper by checking items off a shopping list, the enzyme tests each part against the DNA sequence it wants to replicate.
It''s well-known that Taq rejects any wrong items in its proverbial shopping cart that rejection is the key to successfully duplicating a DNA sequence. It''s surprising that Taq is often dissected with correct bases. It''s the equivalent of a shopper buying half a dozen identical tomatoes, placing them in the cart, and testing all of them when only one can is required.
Taq is much, much less powerful in its job than it might be.
According to Philip Collins, a professor at the University of Illinois of Physics and Astronomy who is a co-author of the new research, the discovery is a step towards revolutionizing medical care. That''s because if scientists understand how Taq functions, they can also understand just how precise a person''s genome is.
According to Collins, every individual has a slightly different genome, many of whom are different in their respective areas. Some of those are ineffective in disease, while others are ineffective in nature. To understand whether these differences are important for proper medicine, you must know exactly where the differences are.
According to Collins, whose laboratory developed nano-scale equipment for studying Taqs behavior. How do you assure to a patient that their DNA has been precisely sequenced when its different from the accepted human genome? Does the patient really have a rare mutation, or did the enzyme simply make a mistake?
This effort may be used to develop improved Taq versions, which will save you time while making DNA copies, according to Weiss.
Every scientific field that relies on accurate DNA sequencing can benefit from a better understanding of Taq''s behavior. For example, scientists rely on assumptions about how DNA changes over time, and those assumptions rely on excellent genetic sequencing.
According to Collins, we had uncovered the human genome for the first time before, but this newfound information from genomics was beginning to be useful if it was accurate.
