On a Mediterranean diet, a Gut Microbome was enriched with weight loss-associated bacteria

On a Mediterranean diet, a Gut Microbome was enriched with weight loss-associated bacteria ...

The green Mediterranean diet (MED) has a significant impact on the human digestive system (i.e., the gut microbiome). A study was recently published in Genome Medicine (https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01015-z) which was focused on translational genomic medicine.

Prof.Iris Shai, director of the Health & Nutrition Innovative International Research Center, the Ben-Gurion University of the Negev, and an adjunct professor from the Harvard School of Public Health, led the research, along with Dr.Ehud Rinott, Dr.Ilan Youngster from Shamir Medical Center and Tel-Aviv University, and several distinguished international experts.

The DIRECT-PLUS research team, led by Prof. Shai, was the first to develop the concept of the green-Mediterranean diet. This modified MED diet is further enriched with dietary polyphenols, which is lower in red/processed meat than traditional healthy MED diet. On top of a daily intake of walnuts (28 grams), participants consumed 3-4 cups of green tea per day and 100 grams (frozen cubes) of duckweed green shake per day. The aquatic green

DIRECT PLUS trial highlights the use of a high-polyphenol-green plant-based diet to improve the microbiome for autologous fecal microbiota transplantation (aFMT)procedure, which benefits both LDL cholesterol and glycemic control, and reduction of age-related brain atrophy.

The results indicated that while all diets induce significant changes to the gut microbiome community, green-MED dieters are much more likely. Interestingly, this development was attributed to the fact that duckweed, a prominent component of this new diet, is introducing rare bacteria to the Western palate, allowing often concealed microbes to flourish under the new gut environment induced by the plant.

The green MED diet involved various microbial changes, including enrichments in the genusPrevotella, a bacteria known for its positive effects on glucose metabolism and insulin sensitivity, while also promoting genetic pathways involved in the reduction of branched-chain amino acids, compounds that are effective in insulin resistance. Finally, the researchers were able to demonstrate that by manipulating specific gut microbes through dieting, the gut microbiome constitutes a valuable mediator between the green dietary pattern and its effects on weight loss

"These findings may further our understanding of the important cross-talk between our nutritional intake, the microbiome, and clinical results," according to Prof. Shai.

We hoped to study how the green MED diet affects the health of its consumers. According to Dr. Ehud Rinott, the first author and member of the BGU School of Public Health, the positive clinical results were significant. We hope that by exploring the role of the gut microbiome in the diets effect, we may further improve and personalize diets in the future."

"These results represent another example illuminating our gut microbiome in health and disease, and they will further our understanding in this challenging field, according to Prof. Ilan Youngster.

You may also like: