A discovery of a human fat inflammation immunization mechanism might assist in obesity treatment

A discovery of a human fat inflammation immunization mechanism might assist in obesity treatment ...

In addition to their studies, Irish and German scientists have just identified how specific immune cells can work together in fat to alleviate weight gain and obesity. Their research has identified new avenues to use the regulation of inflammation in fat tissue, thereby identifying new strategies to reduce obesity.

There is a worldwide epidemic in obesity among adults and children, with obese people predisposed to developing diabetes, cardiovascular disease, and cancer. New therapies are needed to assist resolve this issue.

Checkpoint proteins and immune cells in the body tissue were altered to cause obesity. In people with obesity (Body Mass Index BMI> 30 kg/m), these changes in checkpoint expression in the visceral fat were predictive of the weight of their peers.

Changes in mice''s so-called immune checkpoint proteins on a Western high-fat diet were then linked to significant reductions in obesity and diabetes.

Professor Padraic Fallon of Trinity College is the subject of a research led by Dr Christian Schwartz, a former EMBO Fellow at Trinity and now a Principal Investigator at the University Hospital Erlangen.

Professor Fallon, who is now living in the Trinity Biomedical Sciences Institute, said that this new research of checkpoint regulation of cells in visceral fat of obese individuals improves our understanding of how the immune system controls diet-induced weight gain, which can lead to conditions such as obesity and type 2 diabetes.

As shown in the COVID-19 epidemic, obese individuals who are infected with SARS-CoV-2 are more likely to develop severe illness that requires intensive treatment and a higher risk of mortality.

We investigated the function of immune checkpoints on specific cells, and it is interesting to see that a small difference on one of the fat cells has such an effect on the outcome of the disease. Only through our basic research using pre-clinical methods, we were able to obtain patient samples and link our findings to human disease. It will be interesting to look at how we may alter this checkpoint now to assist individuals with obesity.

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