The aprocessthatinvolves the study of and growing thin slices of pig heart tissue which includes both the epicardium---the mostexternal layerof the heart that contains cells that can promoteitsrecovery, and the foundation''s heartmuscle.
The team treated the epicardial slices with stimulating compounds, indicating that cells become activated in a way thatreplicates what happens in the heart following a heart attack.The newprocess was able to reproduceobservations typically obtained inlive animal experiments.
Dr Paola Campagnolo, the author of the research and senior lecturer in Molecular Cardiovascular Sciences at the University of Surrey, has said that she has a passion for research.
This study reflects the University of Surrey''s One Health, One Medicine philosophy, as our study would aid us understand how to manage heartattacks without having to utilize live animals in the research. We are hopeful that our approach will improve human health outcomes and reduce the dependence on animal experiments in cardiovascular science.
According to the British Heart Foundation, around 7.6 million people have heart or circulatory diseases in the United Kingdom. This disease is responsible for a quarter of their total deaths in the United Kingdom.
The ability of the heart to recover afteraninjury is weakened by the low number of withinitstissue. The currentresearchmodelsand strategies aimed at improving thetheartsrepairprocess are mainly based on surgical methods performed onlaboratoryanimals.
Dr DavideMaselli, the first author of the paper, said: "Dr. DavideMaselli is the author of a paper," according to the postdoctoral research associate.
Thiswork provides an innovative platform to investigate the healing from a heart attack. We believe that our research may be useful to dissect theroleof different cells in the reparative process. It is extremely important that every step forward in this fielddeliversa clinical perspective for the patients, while reducing the burden on researchanimals.
The findings, published in the journal npjRegenerative Medicine, proposes a system to study the cardiac regeneration in a laboratory dish, which might therefore result in a reduction in the number of small animals employed in cardiovascular research.