Localization and Isomer Differentiation of Phosphorylated Peptide Post-Translational Modification Site

Localization and Isomer Differentiation of Phosphorylated Peptide Post-Translational Modification Si ...

Protein phosphorylation is an important post-translational modification (PTM) as it involves a wide spectrum of dynamic cellular processes. However, PTM site localization and quantification of phosphopeptides by collision induced dissociation MS/MS may be difficult, and phospho-peptides may exhibit a partial neutral loss of the phospho group. Download this app note to learn how electron activated dissociation fragmentation:

  • Shows promising performances for the robust and accurate quantification of labile PTMs
  • Generates strong and distinct PTM site localization ions
  • Offers a detailed characterization of the modified peptides of interest

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