Reduction in Gamma Brain Waves Linked to Psychotic Disorders

Reduction in Gamma Brain Waves Linked to Psychotic Disorders ...

Nevertheless, the development of gamma waves, known for their role in the proper brain transmission, has led to the development of psychotic symptoms, according to a research conducted in the American Journal of Psychiatry.

According to Stephan Eliez, the greatest frequency of the brain rhythms, plays a significant role in the development of schizophrenia symptoms, as did the researchers. However, we were able to confirm that this impaired synchronization of neural communication pathways observed in mice actually exists.

Genetic predisposition

People with a chromosomal microdeletion 22q11 have a 25 to 30% chance of developing schizophrenia in adulthood. Consequently, they are a particularly significant at-risk population for studying the cerebral development of this disease, according to Valentina Mancini, a doctoral student at Stephan Eliezs laboratory and the first author of this study. In order to detect any disturbance in brain communication, the scientists then measured gamma wave activation following an auditory stimulus in 22q11 patients of all ages

During development, children and adolescents at genetic risk of schizophrenia were exposed to the same symptoms as those who died in the disease, according to Vincent Rochas, a scientific collaborator. This maturation is absent in 22q11 patients, regardless of their age, implying an abnormal development of neural oscillations in adolescents.

Intervening as early as possible

The researchers claim that the gamma-band activation deficit is linked to the severity of psychotic symptoms, such as auditory hallucinations, which have confirmed the existence of a neurobiological progression of the disease. Moreover, research on mice showed that specific neuroleptic therapies are effective in correcting neural dysfunctions; therefore, the gamma-band impairments identified here could be restored by means of non-invasive neurostimulation targeting the affected brain regions, thus opening the way to completely new therapeutic

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