In preclinical studies, using the timsTOF and MALDI-2 platforms to evaluate Pharmacodynamics and Pharmacokinetics

In preclinical studies, using the timsTOF and MALDI-2 platforms to evaluate Pharmacodynamics and Pha ...

The pharmacodynamic and pharmacokinetic properties of a drug are essential for successful treatment to the clinic. However, cost-effective methods to measure these parameters at the system level in pre-clinical studies are lacking. We present a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, and absolute drug quantitation across different biological matrices, as well as in vitro isotope tracing and

  • Learn about innovative metabolomics workflows
  • Discover how the Bruker timsTOF Pro and fleX systems can be used in metabolomics workflows
  • Learn how the MALDI-2 post-ionization laser can see never before observed compounds

*Not for medical use, but for research use.

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