Vaccines and therapeutics for COVID-19 and Beyond using plant-based techniques

Vaccines and therapeutics for COVID-19 and Beyond using plant-based techniques ...

Dr.Kathleen Hefferon, a Cornell University microbiologist, discussed how and why plant-derived vaccinations are being developed to treat Ebola, Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19).

Traditional vaccinations may be extremely costly and in short supply, according to Dr. Hefferon.

Plant-based vaccinations do not require needles, syringes, or training for their administration. Quite often, they can be stored ambiently, reducing the need for expensive cold storage systems. As such, they can help to alleviate some of the difficulties encountered with large-scale vaccination programs in developing countries.

Hefferon emphasized how plants may be utilized to enhance the availability of inexpensive pharmaceuticals to even the most remote of places. With only 6.6 percent of people in low-income countries receiving at least their first dose of a COVID-19 vaccination (as of February 2022), elaborating a vaccination delivery to remote locations is crucial.

The SARS-CoV-2 spike protein is a powerful antioxidant capable of producing effective immune responses against the virus.1, The research has included several prolines into a furin domain, which helps stabilize the [spike protein] trimer. We have replaced [the transmembrane domain] with a KDEL motif, which is an endoplasmic reticulum retainer.

A geminivirus was then inserted the spike protein open reading frame, which is used to infect plants and causes the transient expression of the virus.

The spike protein produced by plants can be used to make a cheaper vaccine for people around the world.

Two biopharma companies have entered plant-based COVID-19 vaccinations into clinical trials at the time of writing.

Click here to see the complete Teach Me in the ten video!

Hefferon discussed her recent research on developing plant virus nanoparticles to target cancer cells and how plant viruses may be used as expression vectors to produce pharmaceuticals. You can see her here.

The majority of Ebola virus outbreaks and cases have occurred in Africa. Inmazeb and Ebanga are two monoclonal antibodies that simultaneously bind to the virus glycoprotein. A vaccine that protects against the most deadly species of ebolavirus has been approved in the United States.

The Middle East respiratory syndrome (MERS) is caused by a coronavirus infection and was first discovered in Saudi Arabia in 2012. Since then, cases outside the Peninsula have occurred in the Republic of Korea, in 2015. MERS is through close contact with an infected person. There are currently no specific therapies for MERS, and vaccinations are being used in clinical trials.

COVID-19 is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first cases of COVID-19 were reported in China in 2019, and the virus has since spread worldwide. Numerous vaccinations have been developed and administered, with the WHO emphasising the importance of vaccine equity.

References to the following categories:

You may also like: