Team proposes a new carrier to deliver chemotherapy medication

Team proposes a new carrier to deliver chemotherapy medication ...

Polyoxometallate nanoclusters will be used as a therapy drug for the chemotherapeutic purpose, which can be achieved either by electrophoresis or by injection into the bloodstream. The development isdescribed in theAIP Conference Proceedings.

We''ve studied molybdenum polyoxometalates, which is formed of molybdenum and iron, together with common oxygen molecules, containing organic groups. Their particularity is that they are a nanocluster to the surface of which a medication can be attached and delivered to the tumor formation. However, these polyoxometallates do not alter their function or morphology, and thus they are capable of functioning and preventing anemia (the development is patented).

Futher scientists intend to create a vector molecule on the polyoxometallate''s surface that may distinguish cancer cells and ensure the binding of the nanocluster to them, bypassing healthy ones.

Researchers analyzed how the nanocluster would interact with doxorubicin, a well-known anticancer antibiotic. It is effective at destroying tumor structures, but has a limited selectivity. High concentrations of the medication used to destroy cancer cells are harmful to the damaged body.

The undisputed advantage of targeted delivery is the possibility to modify the medication dosage. According to Uleksandr Ostroushko, the head of theSection of Chemical Material Science at UrFU has demonstrated that too high a concentration of doxorubicin in a polyoxometallate capsule will also result in the death of healthy cells.

The research was carried out on cervical cancer cell structures (carcinoma), and this method of delivery may be applied to other tumors in the future. Researchers plan to conduct preclinical experiments on laboratory animals to assess the therapeutic effectiveness and safety of the system. The authors note that nanocluster compounds will be able to deliver other medications, such as anti-inflammatory ones. The research will help to improve the accuracy of targeted medications.

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