According to a study in the United Kingdom, mRNA COVID-19 vaccinations have the biggest booster impact
According to a British study published on Thursday, COVID-19 vaccines made by Pfizer and Moderna that employ mRNA technology provide the greatest boost to antibody levels when given 10-12 weeks after the second dose.
The "COV-Boost" study was cited by British officials when they stated that Pfizer and Moderna were preferred for use in the country's booster campaign, but the data has only been made public right now.
Six out of the seven boosters examined increased immunity after first vaccination with Pfizer-BioNTech's vaccination, whereas all seven increased immunity when given after two doses of AstraZeneca's vaccination, according to the study.
"A third dose will be effective for many of the vaccines we've tested and in various combinations," Professor Saul Faust, an immunologist at the University of Southampton and the trial's head, told reporters.
The study found that a full dose or a half dose of Pfizer or a full dose of Moderna boost both antibody and T-cell levels, regardless of whether the individual initially received Pfizer or AstraZeneca, was effective.
When AstraZeneca, Novavax, Johnson & Johnson, and Curevac were given as boosters, they raised antibody levels for either initial vaccination, but to a lesser degree. Valneva, on the other hand, did not provide a boost for Pfizer.
booster shots, according to the study, also helped to develop a broad T-cell response against the Beta and Delta variants, which may play a crucial role in longer-term protection.
"T-cell (response) appears to be broader compared to all variant strains, which gives us hope that a variant strain of the virus may be handled, hospitalisation and death, if not prevention of infection, by the current vaccinations," Faust added.
The study pre-dated the prevalence of the Omicron variant of worry, but Faust said he had exchanged samples with the UK Health Security Agency to obtain Omicron data as well.
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