Doctors Told About An Unusual Condition In The Body When Cancer Appears
American researchers from the Massachusetts Institute of technology and the Klarman Cell Observatory at the broad Institute spoke about a strange state of cells in the body that occurs in the early stages of the development of a malignant tumor and then helps the cancer adapt to chemotherapy.
Cancer resistance to chemotherapy is one of the main obstacles to achieving permanent remission. There is a widespread belief that such drug resistance is based on unique genetic mutations in tumors. However, recently, scientists have been paying more attention to non-genetic changes in cancer cells that help the latter adapt to drugs, explained researchers from the United States.
One of the ways to develop resistance (resistance) of cancer cells is to change their identity. For example, a prostate cancer cell that is sensitive to hormone-blocking therapy can "turn" into a cell type that does not require a hormone for its growth. This is due to changes in gene expression. That is, using cells that turn certain genes on and off. In this connection, one tumor may be different in its composition. This heterogeneity creates problems for treatment since one drug is unlikely to work against several types of cells at once.