Natural Occurring Compound Might Enhance Muscle Regeneration

Natural Occurring Compound Might Enhance Muscle Regeneration ...

Researchers at the University of Ottawa have discovered a unique form of cell communication that controls muscle repair. Their latest study in mice and human tissues demonstrates that hyaluronic acid may be the key component that manages this fundamental interaction.

The results have been published in the journalSciencein a paper titled, JMJD3 activated hyaluronan synthesis drives muscle regeneration in aninflammatory environment.

According to the researchers, Muscle stem cells (MuSCs) reside in a specific niche that guarantees their regenerative capacity. Although we know that innate immune cells invade the niche in response to injury, it remains unclear how MuSCs adapt to this altered environment for initiating repair. Here, we demonstrate that inflammatory cytokine signaling from the regenerative niche impairs the ability of Quiescent MuSCs to continue functioning.

Jeffrey Dilworth, PhD, senior scientist at the Ottawa Hospital and professor at the University of Ottawa and senior author on the research, believes immune cells must penetrate the tissue quickly and remove the damage before stem cells begin repair. After about 40 hours, after the cleanup job is completed, the muscle stem cells wake up and begin repair.

When muscle damage occurs, stem cells start producing and coating themselves with hyaluronic acid. Once the coating gets thick enough, it blocks the immune signals and triggers the muscle stem cells to wake up.

Dilworth and his colleagues studied how muscle stem cells controlled the production of hyaluronic acid using epigenetic marks on the Has2 gene.

According to lead author Kiran Nakka, PhD, aging is linked with chronic inflammation, muscle weakness, and a reduced capacity of muscle stem cells to wake up and repair damage. This study was carried out as part of his postdoctoral fellowship.

The authors noted that hyaluronic acid's regenerative ability appears to be dependent on it being produced by muscle stem cells. The team is currently investigating whether medicines that alter the epigenetics of muscle stem cells may be used to enhance their production of hyaluronic acid.

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